I love most if not all Bioware games, but the general space opera-y feel of mass Effect is up near the top. A little about how I tend to play:
Gender: typically end up as Male Shepard with custom look. Though I did nab a neat Bruce Campbell Shepard off the 'net that I'll have to use my next play through.
ME1- Infiltrator ME2: Infiltrator or Soldier. I played a Vanguard once and thought it was okay, I guess I just love the sniping too much to deviate too far from it. Nothing quite like seeing a poor shlub go from full health to nothing as his head turns into a watermellon at a Gallahger concert.
Playstyle: ME1: Paragon. ME2: Paragon with a dash of Renegade - what can I say? I like being the nice guy hero, being a jerk of any type tends not to sit well with me. That said I won't hesitate to shove the dude out the window, and if I'm running with Jack or Zaeed I tend to go more towards the Renegade side of things. Otherwise it's paragon.
Favorite squad mates: Garrus, Tali The only two characters that if they are not part of the squad in ME3 I will be enraged over. As said before Garrus is the ultimate bro and buddy to my Shepards however his loyalty mission is generally done in the Renegade fashion as I don't suffer Traitors well, not matter how repentant they may be. Tali I utterly adore I DO Admit that it's the mainly the voice actresses fault for that, love that accent and the mannerisms. Wringing her hands nervously, Babbling a mile a minute, etc. Adorable to me yet perfectly able to handle herself and no I do NOT think they should show what Quarians look like, I like a little mystery. Kasumi is a special mention here, mainly because she's DLC and has only a handful of interactions, what I saw I really enjoyed though.
Disliked Squad mates: Jack, Zaeed. Zaeed was just sorta there, there could have been more done with him I feel, but overall he tends to sit in his area. Jack I never liked since the character introduction, but I'll be honest. She's gotten more tolerable than when I first started out. The attitude, look, and overall characterization of the character is something I could do without. That's not to say that I don't want the character in the game, just that she's not my cup of tea. She's most often on the sidelines, sitting down in her little hole in Engineering. I will admit to not running her romance option but I have viewed the culmination elsewhere.
Liked NPCs: Conrad Conrad's an idiot and a fanboy. Some may think he's annoying as hell and he is, but I find it amusing that Shepard has such a..err.. 'dedicated' fanboy.
(Edit) Also forgot to mention the Asari bartender on Illium. That was a great character and I always end up exhausting every convo option with that one. I'd love to see that one return somehow.
Disliked NPC: Turian Council member. I loathe that damn turian. 'nuf said.
Most hated opponent: Those floating spider husk things ALWAYS give me trouble. Ugh. Hate dealing with them.
Love interest: ME1 - none (if forced to pick, then Liara) ME2 - It's all about Tali.